Автор: Umida Категория: Статьи (кафедра)
Дата публикации Просмотров: 3103

Antiangiogenetic therapy of patients with recurrent type of Non-Hodgkin lymphoma S.N.Navruzov, *Z.A.Olimova National Cancer Research Center, 383 Farobi, Tashkent, Uzbekistan Background:Angiogenesis plays a central role in the development of tumors, and VEGF is the dominant proangiogenic factor.We consider the process of angiogenesis and its role in tumor development, as well as the key role of VEGF in the regulation of tumor angiogenesis. Patients and methods: The research is based on a study of the level of these parameters in serum 121 patients with recurrent form of NHL and 40 healthy human volunteers who wished to take part in the research. The mean age was 52,3 ± 0,8 years. All patients in the initial state determined the content of VEGF in serum by enzyme immunoassay analyzer for ELISA open Alisei "Seac" (Italy). The process of angiogenesis can be activated at different stages of tumor development (depending on the type and conditions of the microenvironment) as critical to its growth. Results:The studies revealed a significant increase in the concentration of vascular endothelial growth factor in the blood of patients with recurrent form of NHL, compared with a group of clinically healthy individuals by 1.6 times. VEGF is one of the most powerful and dominant pro-angiogenic factors and the most important of the described angiogenetic factors during the whole lifecycle of the tumor. Given that endothelial cells and VEGF genetically stable, VEGF is produced continuously, this factor could be a potential target for early precision block VEGF. To stop the further growth of tumor vessels in the treatment, we used Bevacizumab(Avastin). Avastin is humanized monoclonal antibody to pro-angiogenic factor of human VEGF. Avastin binds to VEGF, thereby blocking the angiogenic cascade. Avastin is active against all major isoforms of human VEGF. Conclusions: Three-component mechanism of Avastin include: regression of the tumor vasculature, "normalization" preserved tumor vasculature, and inhibition of growth of the new blood vessels. Taking into account the important role of angiogenesis in tumor development, antiangiogenic therapy could be one of the main methods of treatment of recurrent forms of NHL together with radiation therapy and chemotherapy.

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